Accurately modeling a condition in vitro has been an ongoing challenge. Although cell line models have helped bring about major breakthroughs in medicine, they are limited in accurately depicting physiological conditions occurring in humans. Over the past several years efforts have been made to develop organ-on-a-chip technology to accurately mimic physiological conditions of various organs in vitro using human derived cells and tissues. In this multi-institute, multi-department, academic-industrial collaborative review, the major developments in the field of organ-on-a-chip (OOAC) have been discussed. Moreover, with the incorporation of artificial intelligence these systems would become essential in accurately modeling disease conditions, including studying drug pharmacology and personalized medicine in real time.
The review titled “Breakthroughs and Applications of Organ-on-a-Chip Technology” was published in June 2022 in the journal Cells.