Cutting-Edge Projects in Cardiovascular Disease Research

AI-Powered Tools for Early Detection and Personalized Treatment of Aortic Dissection

Aortic dissection is a serious heart condition that affects thousands of people in the United States every year and can be difficult to predict and treat. Researchers are developing an advanced artificial intelligence (AI) system that combines detailed medical images with biomechanical models of the aorta to assess each patient’s risk of complications more accurately. By analyzing key features inside the blood vessel, this tool aims to help doctors identify high-risk patients early, personalize treatment decisions, and potentially improve survival rates. In the future, the project could lead to a clinician-friendly web dashboard, offering individualized risk maps and recommendations that support better, safer care for people facing aortic dissection.

Faculty List

Elvin Blanco, PhD

Houston Methodist

John Cooke, MD, PhD

Houston Methodist

Carly Filgueira, PhD

Houston Methodist

Nilesh Mathuria, MD

Houston Methodist

Maham Rahimi, MD, PhD, RPVI

Director of Student Research; Houston Methodist

Publications and Grants

Our interdisciplinary research integrates clinical expertise with advanced engineering to revolutionize the field of cardiovascular disease. We are dedicated to delivering meaningful improvements for patients and making a lasting impact on the broader healthcare community.

Surgeons have developed a new technique to safely perform kidney transplants on patients whose leg arteries are heavily hardened by calcium and disease, a common problem that can make standard procedures risky or impossible. This innovative method may pave the way for more successful transplants among people with severe arterial disease.

When an artificial blood vessel (aortic endograft) fails, removing it is often risky and sometimes life-threatening, because traditional techniques can damage artery walls and cause severe bleeding. Doctors and engineers have designed a new tool—shaped with a special taper and gentle rolling beads— that slips around the implant and protects the artery during removal. With this promising invention, major aortic surgeries may soon become much safer for patients who need life-saving medical intervention.

Training surgeons to manage ruptured aortic aneurysms—a life-threatening emergency—is challenging because the rapid, unpredictable nature of the condition limits opportunities for hands-on training, and current educational tools often fail to provide adequate preparation. Now, researchers have developed a lifelike model using preserved human cadavers and synthetic tissue, even recreating a beating, blood-flowing aorta. The hope is that this breakthrough will help future surgeons gain vital hands-on skills safely, leading to better outcomes for patients in emergencies.