Advancing Neuroscience: Current Research Initiatives

New Brain-Boosting Patch Could Improve Memory in Alzheimer’s by Supporting Gut Health

Texas A&M and Houston Methodist researchers are developing an innovative, ultra-flexible brain stimulation patch to explore new ways to improve brain and gut health in Alzheimer’s disease. This skin-like, non-invasive device gently delivers electrical stimulation to the brain of mice with Alzheimer’s, while scientists track effects on memory, inflammation, and the gut’s community of microbes. The team hopes to show that this soft, wearable technology can safely influence the gut-brain axis, reduce brain inflammation, and protect against memory loss—all without drugs. The results could pave the way for future therapies that use gentle brain stimulation to improve gut and brain health, offering hope for new, non-drug interventions for Alzheimer’s and other neurological conditions.

Faculty List

Robert Krencik, PhD

Houston Methodist

Andrew Lee, MD

Houston Methodist

Jiho Shin, PhD

Texas A&M College of Engineering

Sonia Villapol, PhD

Houston Methodist

Publications and Grants

Our interdisciplinary research combines clinical expertise with innovative technologies to drive progress in neuroscience. Through pioneering studies and grant-supported projects, we are dedicated to enhancing patient care and making a meaningful impact on the understanding and treatment of neurological disorders.

Astronauts on long missions in space often develop a puzzling set of vision changes and eye problems, known as Spaceflight Associated Neuro-Ocular Syndrome (SANS). Scientists still don’t fully understand what causes these changes, which can include blurring of near vision, swelling of the optic nerve, and other subtle eye structure shifts. This new research dives into the complex mix of factors at play—including shifts in bodily fluids due to microgravity, possible changes in brain and eye pressure, genetic risks, nutrition, and even exposure to space radiation.  Researchers hope that by untangling the causes behind SANS, we can protect astronaut eyesight and safely explore deeper into the cosmos. 

Scientists have developed a new technology that uses tiny capsules filled with human brain cells—called astrocytes—to deliver healing proteins directly where they’re needed in the brain. By engineering these cells to produce a powerful anti-inflammatory substance, researchers were able to reduce harmful inflammation in both lab-grown mini-brains and in living mouse brains. The study marks an exciting step toward future therapies for neurological diseases like Alzheimer’s, Parkinson’s, and brain injury, all of which involve damaging inflammation. This gentle, targeted approach could one day help restore normal brain function where current treatments fall short—offering hope for millions battling neurodegenerative conditions. 

new study in mice shows that taking probiotics—the “good” bacteria often found in yogurt and supplements—can protect the brain and improve recovery after traumatic brain injury, especially in males. The probiotic treatment boosted beneficial gut microbes, reduced brain inflammation, and improved motor skills and mood-related behaviors. For females, the benefits were more focused on emotional well-being. Researchers say these promising results highlight the power of the gut-brain connection and suggest that probiotics might one day play an important role in personalized treatments for brain injury, tailored by sex.